The Revolution in Migraine Treatment: The Emergence of CGRP Medications
Migraines, a debilitating neurological condition affecting millions globally, have historically been challenging to treat effectively. Patients often struggled with managing severe, recurrent headaches, nausea, sensitivity to light and sound, and considerable disruptions to daily life. Thankfully, groundbreaking advancements in migraine management have arrived in the form of CGRP-targeted medications.
Dr. Sherif Makar
6/12/20251 min read
What is CGRP?
Calcitonin Gene-Related Peptide (CGRP) is a neurotransmitter found abundantly in the nervous system. Research has shown that CGRP levels significantly rise during migraine attacks, suggesting its crucial role in causing and prolonging migraine pain. Targeting CGRP and its receptors has thus become a promising therapeutic strategy.
The CGRP Medication Breakthrough
CGRP medications, also known as monoclonal antibodies, are specifically designed to block CGRP or its receptors, effectively preventing migraine attacks before they start. Unlike traditional migraine medications, these treatments are more precise, resulting in fewer side effects and better overall patient outcomes.
Several CGRP inhibitors are now FDA-approved, including:
Aimovig (erenumab)
Ajovy (fremanezumab)
Emgality (galcanezumab)
Vyepti (eptinezumab)
These medications have significantly reduced migraine frequency, intensity, and duration for many patients, offering life-changing relief and improved quality of life.
Who Can Benefit from CGRP Medications?
Patients experiencing frequent episodic migraines (typically defined as 4 or more migraine days per month) or chronic migraines (15 or more headache days per month, with migraines on at least 8 of those days) may benefit greatly from CGRP-targeted therapies. Individuals who haven't responded adequately to other preventive treatments often find relief with CGRP inhibitors.
Advantages of CGRP Medications:
Reduced frequency and severity of migraines
Improved daily functioning and productivity
Fewer side effects compared to traditional migraine medications
Easy administration via monthly injections or quarterly infusions (depending on medication)
The Future at Charis Neurology
At Charis Neurology, we're committed to offering cutting-edge neurological care. We're excited to provide our patients access to these innovative CGRP therapies, personalizing treatment plans tailored specifically to each individual's unique medical history and migraine patterns.
If migraines severely impact your daily life, we encourage you to explore these groundbreaking treatments with our experienced neurology team. Relief is possible, and we're here to guide you every step of the way.
To schedule a consultation or learn more about CGRP medications, contact us today. Let's take the first step toward reclaiming your life from migraines.

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